ABSTRACT
Objective To compare the efficacy of Shaaban and low molecular weight heparin in the prevention and treatment of deep venous thrombosis of lower extremity after knee replacement. Methods January 2011 to 2013 year in January in our hospital 120 cases of knee joint replacement patients as the research object, divided into observation group and control group, the observation group were treated by oral anticoagulant treatment of Lee Shaaban, the control group by subcutaneous injection of low molecular weight heparin treatment than patients were compared between the two groups after deep vein thrombosis the incidence of 14d after treatment, adverse reactions and blood coagulation indexes in patients with drug. Results The observation group of patients with deep vein thrombosis rate was 1.67%, significantly lower than the control group 13.34%, the difference was statistically significant (P<0.05); no statistical significance in two groups of patients after the treatment of 14d PLT, APTT and PT level difference; the observation group of patients with drug adverse reaction incidence rate was 5%. The 13.34% was significantly lower than the control group, the difference was statistically significant (P<0.05). Conclusion Compared with low molecular weight heparin, the incidence of deep vein thrombosis is lower, the adverse reactions are less, and the curative effect is more obvious after applying Shaaban's knee replacement.
ABSTRACT
Objective To explore the clinical efficacy of combination therapy with promethrin and gliclazide sustained-release tablets in the treatment of obese patients with type 2 diabetes mellitus with poor blood glucose control. Methods Selected from December 2015 to March 2017 in our hospital treated 96 cases of insulin treatment of poor blood glucose control in obese patients with type 2 diabetes, were randomly divided into study group and control group, 48 cases in each group.The study group were treated with Novolin 70/30(Novolin 30R)combined with Gliclazide Sustained-release Tablets,while the patients in control group were treated with Novolin 30R combined with repaglinide. Results The decrease of FBG, 2h PG, HbAlc, HOMA-IR and the increase of HOMA-IS in the study group were better than those in the control group (P<0.05).There was no significant difference in BMI between the two groups after treatment and BMI in the control group was significantly higher than that before treatment (P<0.05),CRP was not statistically significant before treatment.Conclusion The application of Novolin 30R and Gliclazide Sustained-release Tablets after treatment can make the use of insulin alone poor glycemic control in obese patients with type 2 diabetes have more desirable clinical efficacy,is conducive to ensuring the safety and effectiveness of drugs.